Association of A1c levels with vitamin D status in U.S. adults: Data from the National Health and Nutrition Examination Survey

Diabetes Care. 2010 Jun;33(6):1236-8.
Authors: Kositsawat J, Freeman VL, Gerber BS, Geraci S.

Objective: Data relating vitamin D status with indices of glucose homeostasis as manifested by A1c in the U.S. adult population are few. Research Design and Methods: We examined the association between serum 25-OH vitamin D and A1c levels in 9773 adults (age ≥ 18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. Results: Serum 25-OH vitamin D levels were inversely associated with A1c levels in subjects age 35 to 74 years (p=0.0045) and those who did not report a history of diabetes mellitus (p=0.0282). Conclusions: These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1c levels for vitamin D insufficiency should be considered.

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